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Quetiapine

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Diyila Dagbani Wikipedia
Quetiapine
type of chemical entity
Yaɣ sheliatypical antipsychotic, heterocyclic compound, dam Mali niŋ
Pahi laresponse to quetiapine Mali niŋ
Di bukaatatima Mali niŋ
Stylized nameQUEtiapine, SEROquel Mali niŋ
Chemical formulaC₂₁H₂₅N₃O₂S Mali niŋ
Canonical SMILESC1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42 Mali niŋ
Active ingredient inSeroquel Mali niŋ
World Health Organisation international non-proprietary namequetiapine Mali niŋ
Legal status (medicine)boxed warning Mali niŋ
Pregnancy categoryAustralian pregnancy category B3, US pregnancy category C Mali niŋ
LiverTox likelihood scoreLiverTox toxicity likelihood category B Mali niŋ
Bachikpani mali tumaalpha blocker, dopamine antagonist, serotonin antagonist, H1 antagonist Mali niŋ
 

Quetiapine, tim ŋɔ nyɛla bɛ ni kɔhiri shɛli tima kɔhibu yuli booni Seroquel, di nyɛla ti'shɛli bɛ ni tooi mali tibiri yiniyahili bee zuɣupuri dambu.[1] Niriba pam gba nyɛla ban yuusiri ka di sɔŋdiba ka bɛ gbihira amaa di nin'biɛri ni lala yaɣili ŋɔ nyɛla din mali barina gari di anfaninima. Di nyɛla ti'shɛli din vanna .[2]

Niri yi vali tim ŋɔ di ni tooi niŋdi o shɛm nyɛ gbihibu, pufahili, timsim niŋbu n ti pahi nangbani kuubu. Di ni tooi lahi niŋdi ninvuɣ so ŋun vali tim ŋɔ shɛm nyɛ ʒim bela bela zɔbu, ʒɛhibu, dabilim pahibu bee yoli yiɣisi yuugi ni din kam pahi.[2] Ninkura ban din ka ʒim pam yi vali tim ŋɔ nyɛla di ni tooi chɛ ka bɛ kɔŋ bɛ nyɛvuya.[2] Paɣapuulana ŋun vali tim ŋɔ puli maa chira ata ni nyɛla din yɛn dam bia maa chandi saha o yi ti dɔɣi nyaaŋa.[2] Quetiapine nyɛla din tumdi n tooi kpariti ʒɛsoya n ti pahi "serotonin" mini "dopamine".[2]

Quetiapine nyɛla bɛ ni daa mali ti'shɛli yuuni 1985 amaa ka alaafee tumanima daa saɣi n ti di zaŋ tum tuma United States yuuni 1997.[3] Lala tim ŋɔ nyɛla din be World Health Organization's tima din mali anfaanima yuya puuni.[4][5] United States tiŋgbani ni, niri ni tooi da tim ŋɔ zaɣ'bɔbugu kamani liɣiri din yiɣisi US$12 yuuni 2017. United Kingdom, goli puuni alaafee tuma duri nyɛla ban tooi yuusiri lala tim ŋɔ ni liɣiri din yiɣisi kamani £60 bin din gbaai 2017.[5] Yuuni 2017, di nyɛla din daa pahi pisopɔin ni ayobu ti'shɛŋa bɛ ni daa sabi n ti niriba ni bɛ da puuni.

Pharmacology

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Pharmacodynamics

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Quetiapine (mini di ni tumdi shɛm )[6][7]
SiteQTPNQTPActionRef
SERT>10,000927Blocker[7]
NET>10,00058Blocker[7]
DAT>10,000>10,000ND[7]
5-HT1A320–43245Partial agonist[7][8]
5-HT1B1,109–2,0501,117ND[7][8]
5-HT1D>10,000249ND[7][8]
5-HT1E1,250–2,40297ND[7][8]
5-HT1F2,240NDND[8]
5-HT2A96–10148Antagonist[7][8]
5-HT2BND14Antagonist[7]
5-HT2C2,502107Antagonist[7]
5-HT3>10,000394Antagonist[7]
5-HT4NDNDNDND
5-HT5A3,120768ND[7]
5-HT61,865503Antagonist[7]
5-HT730776Antagonist[7]
α1A22144Antagonist[7]
α1B3995Antagonist[7]
α2A2,230–3,630237Antagonist[7][8]
α2B90–747378Antagonist[7][8]
α2C28.7–350736Antagonist[7][8]
β1>10,000>10,000ND[7][8]
β2>10,000>10,000ND[7][8]
D1712214Antagonist[7]
D2245196Antagonist[7]
D2L700NDAntagonist[8]
D2S390NDAntagonist[8]
D3340–483567Antagonist[7][8]
D41,2021,297Antagonist[7]
D4.21,600NDAntagonist[8]
D51,7381,419Antagonist[7]
H12.2–113.5Antagonist[7][8]
H2>10,000298Antagonist[7]
H3>10,000>10,000ND[7]
H4>10,0001,660ND[7]
M185839Antagonist[7]
M21,339453ND[7]
M3>10,00023Antagonist[7]
M4542110ND[7]
M51,94223Antagonist[7]
σ1220–3,651>10,000ND[7][8]
σ21,3441,050ND[7]
NMDA
(PCP)		>10,000NDAntagonist[7]
VDCC>10,000NDND[7][8]
hERGND>10,000
(IC50)		ND[7]
Values are Ki (nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site. All data are for human cloned proteins, except σ1 (guinea pig), σ2 (rat), and VDCC (rat).[7][8]

Quetiapine nyɛla din tumdi kamani lahabali shɛli din be teebuli shɛli din be zuɣusaa maa :[9][10][11][12][13][14][15][16]

Kundivihira

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  1. ↑ (December 2010) "Second-generation antipsychotics for major depressive disorder and dysthymia". The Cochrane Database of Systematic Reviews (12): CD008121. DOI:10.1002/14651858.CD008121.pub2. PMID 21154393.
  2. 1 2 3 4 5 A chirim ya: Invalid <ref> tag; no text was provided for refs named "AHFS2017".
  3. ↑ (April 2007) "Quetiapine in the treatment of schizophrenia and related disorders". Neuropsychiatric Disease and Treatment 3 (2): 219–35. DOI:10.2147/nedt.2007.3.2.219. PMID 19300555.
  4. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  5. 1 2 British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. 383. ISBN 978-0857112989.
  6. ↑ PDSP Ki Database. University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Archived 27 Silimin gɔli April 2021 at the Wayback Machine
  7. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 (September 2008) "N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity". Neuropsychopharmacology 33 (10): 2303–12. DOI:10.1038/sj.npp.1301646. PMID 18059438.
  8. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 (March 1996) "Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding". Psychopharmacology 124 (1–2): 57–73. DOI:10.1007/bf02245606. PMID 8935801.
  9. ↑ AstraZeneca. "Seroquel (quietapine fumarate) tablets". 276521. Archived 2008-04-14 at the Wayback Machine
  10. ↑ (November 2000) "Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds". Life Sciences 68 (1): 29–39. DOI:10.1016/S0024-3205(00)00911-5. PMID 11132243.
  11. ↑ Davis, Kenneth L; Neuropsychopharmacology, American College of (2002). Neuropsychopharmacology: the fifth ... - Google Books. ISBN 978-0-7817-2837-9.
  12. ↑ Seroquel Official FDA information, side effects and uses. Drugs.com. Archived 2012-06-04 at the Wayback Machine
  13. ↑ AstraZeneca Pharmaceuticals LP (March 2011). SEROQUEL (quetiapine fumarate) tablet, extended release. National Library of Medicine. Archived 2021-08-29 at the Wayback Machine
  14. ↑ National Institute of Mental Health. PDSD Ki Database (Internet) [cited 2013 Sep 18]. Chapel Hill (NC): University of North Carolina. 1998-2013. Available from: Archived copy. Archived Silimin gɔli November 8, 2013, at the Wayback Machine
  15. ↑ (September 2008) "N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity". Neuropsychopharmacology 33 (10): 2303–12. DOI:10.1038/sj.npp.1301646. PMID 18059438.
  16. ↑ (September 2013) "Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders". Frontiers in Psychiatry 4: 102. DOI:10.3389/fpsyt.2013.00102. PMID 24062697.
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