Propofol

Tɛmplet:Infobox drug/title
Names
Trade names	Diprivan, others
	IUPAC name 2,6-diisopropylphenol;
Clinical data
Main uses	General anesthesia, sedation for mechanically ventilated adults, procedural sedation
Side effects	Irregular heart rate, low blood pressure, burning sensation at the site of injection, cessation of breathing
WHO AWaRe	Script error: No such module "WDfetch".
Dependence risk	Physical: very low (seizures); Psychological: no data
Addiction risk	Moderate
Pregnancy; category	Tɛmplet:Infobox drug/pregnancy category
Routes of; use	Intravenous
Onset of action	15–30 seconds
Duration of action	~5–10 minutes
External links
AHFS/Drugs.com	Tɛmplet:Drugs.com
Legal
[[Regulation of therapeutic goods \|Tɛmplet:Engvar data]]	Tɛmplet:Infobox drug/licence
Legal status	Tɛmplet:Infobox drug/legal status
Pharmacokinetics
Bioavailability	NA
Protein binding	95–99%
Metabolism	Liver glucuronidation
Elimination half-life	1.5–31 hours
Excretion	Liver
Identifiers
CAS Number	Tɛmplet:Infobox drug/formatCASnumber; Tɛmplet:Infobox drug/formatCASnumber;
PubChem CID	Tɛmplet:Infobox drug/formatPubChemCID; Tɛmplet:Infobox drug/formatPubChemCID;
PubChem SID	Tɛmplet:Infobox drug/formatPubChemSID; Tɛmplet:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Tɛmplet:Infobox drug/formatIUPHARBPS; Tɛmplet:Infobox drug/formatIUPHARBPS;
DrugBank	Tɛmplet:Infobox drug/formatDrugBank; Tɛmplet:Infobox drug/formatDrugBank;
ChemSpider	Tɛmplet:Infobox drug/formatChemSpider; Tɛmplet:Infobox drug/formatChemSpider;
UNII	Tɛmplet:Infobox drug/formatUNII; Tɛmplet:Infobox drug/formatUNII;
KEGG	Tɛmplet:Infobox drug/formatKEGG; Tɛmplet:Infobox drug/formatKEGG;
ChEBI	Tɛmplet:Infobox drug/formatChEBI; Tɛmplet:Infobox drug/formatChEBI;
ChEMBL	Tɛmplet:Infobox drug/formatChEMBL; Tɛmplet:Infobox drug/formatChEMBL;
NIAID ChemDB	Tɛmplet:Infobox drug/formatChemDBNIAID; Tɛmplet:Infobox drug/formatChemDBNIAID;
PDB ligand	Tɛmplet:Infobox drug/formatPDBligand; Tɛmplet:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Tɛmplet:Infobox drug/formatCompTox; Tɛmplet:Infobox drug/formatCompTox;
ATC code	Tɛmplet:Infobox drug/formatATC; Tɛmplet:Infobox drug/formatATC;
Chemical and physical data
Formula	Tɛmplet:Infobox drug/chemical formula
Molar mass	Tɛmplet:Chem molar mass
3D model (JSmol)	Tɛmplet:Infobox drug/formatJmol; Tɛmplet:Infobox drug/formatJmol;
	SMILES CC(C)c1cccc(c1O)C(C)C;
	InChI InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3Tɛmplet:Stdinchicite; Key:OLBCVFGFOZPWHH-UHFFFAOYSA-NTɛmplet:Stdinchicite;

Tɛmplet:Infobox drug/maintenance categories

Propofol, bɛ lahi mi shɛli Diprivan la nyɛla tila shɛli di tumdi yomyom ka di tuma che ka niri yiri o maŋ ni ka lahi tahiri tamsim na^[4] Di tuma ni be shɛli n tooi nye saha shɛli bɛ ti yi niŋ ansthesia bee bɛ ti yen che bari shɛba bɛ ni tiri vuhim gbihi talahi.^[4]

References

↑ Propofol. Archived 3 Silimin gɔli January 2019 at the Wayback Machine
1 2 3 4 5 Propofol. The American Society of Health-System Pharmacists. Archived 9 Silimin gɔli October 2016 at the Wayback Machine
↑ Ruffle JK (November 2014). "Molecular neurobiology of addiction: what's all the (Δ)FosB about?". Am J Drug Alcohol Abuse 40 (6): 428–437. DOI:10.3109/00952990.2014.933840. PMID 25083822. “Propofol is a general anesthetic, however its abuse for recreational purpose has been documented (120). Using control drugs implicated in both ΔFosB induction and addiction (ethanol and nicotine), similar ΔFosB expression was apparent when propofol was given to rats. Moreover, this cascade was shown to act via the dopamine D1 receptor in the NAc, suggesting that propofol has abuse potential (119)”
1 2 Propofol. The American Society of Health-System Pharmacists.

[1] Propofol. Archived 3 Silimin gɔli January 2019 at the Wayback Machine

[AHFS2016-2] 1 2 3 4 5 Propofol. The American Society of Health-System Pharmacists. Archived 9 Silimin gɔli October 2016 at the Wayback Machine

[What_the_ΔFosB?-3] Ruffle JK (November 2014). "Molecular neurobiology of addiction: what's all the (Δ)FosB about?". Am J Drug Alcohol Abuse 40 (6): 428–437. DOI:10.3109/00952990.2014.933840. PMID 25083822. “Propofol is a general anesthetic, however its abuse for recreational purpose has been documented (120). Using control drugs implicated in both ΔFosB induction and addiction (ethanol and nicotine), similar ΔFosB expression was apparent when propofol was given to rats. Moreover, this cascade was shown to act via the dopamine D1 receptor in the NAc, suggesting that propofol has abuse potential (119)”

[AHFS20162-4] 1 2 Propofol. The American Society of Health-System Pharmacists.

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