Morphine

Tɛmplet:Infobox drug/title
Names
Pronunciation	/ˈmɔːrfiːn/
Trade names	Statex, MSContin, Oramorph, Sevredol, and others
	IUPAC name (4R,4aR,7S,7aR,12bS)-3-Methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;
Clinical data
Drug class	Opioid
Main uses	Severe pain
Side effects	Decreased respiratory effort, low blood pressure, abuse
WHO AWaRe	Script error: No such module "WDfetch".
Dependence risk	High
Addiction risk	High
Pregnancy; category	Tɛmplet:Infobox drug/pregnancy category
Routes of; use	Inhalation (smoking), insufflation (snorting), by mouth (PO), rectal, subcutaneous (SC), intramuscular (IM), intravenous (IV), epidural, and intrathecal (IT)
Onset of action	5 minutes (IV), 15 minutes (IM), 20 minutes (PO)
Duration of action	3–7 hours
Defined daily dose	100 mg (by mouth); 30 mg (injection, rectal)
Urine detection	2 to 5 days
External links
AHFS/Drugs.com	Tɛmplet:Drugs.com
Legal
[[Regulation of therapeutic goods \|Tɛmplet:Engvar data]]	Tɛmplet:Infobox drug/licence
Legal status	Tɛmplet:Infobox drug/legal status
Pharmacokinetics
Bioavailability	20–40% (by mouth), 36–71% (rectally), 100% (IV/IM)
Protein binding	30–40%
Metabolism	Liver 90%
Elimination half-life	2–3 hours
Excretion	Renal 90%, biliary 10%
Identifiers
CAS Number	Tɛmplet:Infobox drug/formatCASnumber; Tɛmplet:Infobox drug/formatCASnumber;
PubChem CID	Tɛmplet:Infobox drug/formatPubChemCID; Tɛmplet:Infobox drug/formatPubChemCID;
PubChem SID	Tɛmplet:Infobox drug/formatPubChemSID; Tɛmplet:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Tɛmplet:Infobox drug/formatIUPHARBPS; Tɛmplet:Infobox drug/formatIUPHARBPS;
DrugBank	Tɛmplet:Infobox drug/formatDrugBank; Tɛmplet:Infobox drug/formatDrugBank;
ChemSpider	Tɛmplet:Infobox drug/formatChemSpider; Tɛmplet:Infobox drug/formatChemSpider;
UNII	Tɛmplet:Infobox drug/formatUNII; Tɛmplet:Infobox drug/formatUNII;
KEGG	Tɛmplet:Infobox drug/formatKEGG; Tɛmplet:Infobox drug/formatKEGG;
ChEBI	Tɛmplet:Infobox drug/formatChEBI; Tɛmplet:Infobox drug/formatChEBI;
ChEMBL	Tɛmplet:Infobox drug/formatChEMBL; Tɛmplet:Infobox drug/formatChEMBL;
NIAID ChemDB	Tɛmplet:Infobox drug/formatChemDBNIAID; Tɛmplet:Infobox drug/formatChemDBNIAID;
PDB ligand	Tɛmplet:Infobox drug/formatPDBligand; Tɛmplet:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Tɛmplet:Infobox drug/formatCompTox; Tɛmplet:Infobox drug/formatCompTox;
ATC code	Tɛmplet:Infobox drug/formatATC; Tɛmplet:Infobox drug/formatATC;
Chemical and physical data
Formula	Tɛmplet:Infobox drug/chemical formula
Molar mass	Tɛmplet:Chem molar mass
3D model (JSmol)	Tɛmplet:Infobox drug/formatJmol; Tɛmplet:Infobox drug/formatJmol;
Solubility in water	HCl & sulf.: 60 mg/mL (20 °C)
	SMILES CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5;
	InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1Tɛmplet:Stdinchicite; Key:BQJCRHHNABKAKU-KBQPJGBKSA-NTɛmplet:Stdinchicite;

Tɛmplet:Infobox drug/maintenance categories

Morphine nyɛla tila shɛli din tibiri biɛrim, ka bie opiate tilaa zuliya puuni , ka di tooi ka di bie tihi, binkɔbiri n ti pahi ninsali nima ni.^[11]^[12]

References

↑ drugs.com Drugs.com international listings for Morphine Archived 14 Silimin gɔli June 2015 at the Wayback Machine Page accessed 2 June 2015
↑ MORPHINE injectable - Essential drugs. Archived 28 Silimin gɔli August 2021 at the Wayback Machine
1 2 Morphine sulfate. The American Society of Health-System Pharmacists. Archived 2 Silimin gɔli May 2015 at the Wayback Machine
↑ Bonewit-West, Kathy; Hunt, Sue A.; Applegate, Edith (2012). Today's Medical Assistant: Clinical and Administrative Procedures (in English). Elsevier Health Sciences. p. 571. ISBN 9781455701506. Archived from the original on 28 July 2020. Retrieved 2 August 2020. Archived 29 Silimin gɔli September 2024 at the Wayback Machine
↑ Whimster, Fiona (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 191. ISBN 978-0-521-43379-2. Archived from the original on 8 September 2017.
↑ Liben, Stephen (2012). Oxford textbook of palliative care for children (2 ed.). Oxford: Oxford University Press. p. 240. ISBN 978-0-19-959510-5. Archived from the original on 8 September 2017.
↑ Rockwood, Charles A. (2009). Rockwood and Wilkins' fractures in children (7th ed.). Philadelphia, Pa.: Lippincott Williams & Wilkins. p. 54. ISBN 978-1-58255-784-7. Archived from the original on 8 September 2017.
1 2 WHOCC - ATC/DDD Index. Archived 4 Silimin gɔli August 2020 at the Wayback Machine
↑ Interpreting Urine Drug Tests (UDT). Archived 25 Silimin gɔli October 2023 at the Wayback Machine
↑ (April 1988) "The bioavailability of rectally administered morphine". Pharmacology & Toxicology 62 (4): 203–5. DOI:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374.
↑ Morphine sulfate. The American Society of Health-System Pharmacists.
↑ (2012) "Endogenous morphine: up-to-date review 2011". Folia Biologica 58 (2): 49–56. PMID 22578954. “Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla.”

[drugs.com-page-1] rugs.com Drugs.com international listings for Morphine Archived 14 Silimin gɔli June 2015 at the Wayback Machine Page accessed 2 June 2015

[MSF2020I-2] MORPHINE injectable - Essential drugs. Archived 28 Silimin gɔli August 2021 at the Wayback Machine

[AHFS2015-3] 1 2 Morphine sulfate. The American Society of Health-System Pharmacists. Archived 2 Silimin gɔli May 2015 at the Wayback Machine

[4] Bonewit-West, Kathy; Hunt, Sue A.; Applegate, Edith (2012). Today's Medical Assistant: Clinical and Administrative Procedures (in English). Elsevier Health Sciences. p. 571. ISBN 9781455701506. Archived from the original on 28 July 2020. Retrieved 2 August 2020. Archived 29 Silimin gɔli September 2024 at the Wayback Machine

[5] Whimster, Fiona (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 191. ISBN 978-0-521-43379-2. Archived from the original on 8 September 2017.

[6] Liben, Stephen (2012). Oxford textbook of palliative care for children (2 ed.). Oxford: Oxford University Press. p. 240. ISBN 978-0-19-959510-5. Archived from the original on 8 September 2017.

[Rockwood2009-7] Rockwood, Charles A. (2009). Rockwood and Wilkins' fractures in children (7th ed.). Philadelphia, Pa.: Lippincott Williams & Wilkins. p. 54. ISBN 978-1-58255-784-7. Archived from the original on 8 September 2017.

[WHO2020DDD-8] 1 2 WHOCC - ATC/DDD Index. Archived 4 Silimin gɔli August 2020 at the Wayback Machine

[9] Interpreting Urine Drug Tests (UDT). Archived 25 Silimin gɔli October 2023 at the Wayback Machine

[pmid3387374-10] (April 1988) "The bioavailability of rectally administered morphine". Pharmacology & Toxicology 62 (4): 203–5. DOI:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374.

[AHFS20152-11] Morphine sulfate. The American Society of Health-System Pharmacists.

[St20122-12] (2012) "Endogenous morphine: up-to-date review 2011". Folia Biologica 58 (2): 49–56. PMID 22578954. “Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla.”

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