Metformin

Tɛmplet:Infobox drug/title
Names
Pronunciation	/mɛtˈfɔːrmɪn/, met-FOR-min
Trade names	Fortamet, Glucophage, Glumetza, others
Other names	N,N-dimethylbiguanide
	IUPAC name N,N-Dimethylimidodicarbonimidic diamide;
Clinical data
Drug class	Biguanide
Main uses	Type 2 diabetes
Side effects	Diarrhea, nausea, abdominal pain, low blood sugar
WHO AWaRe	Script error: No such module "WDfetch".
Pregnancy; category	Tɛmplet:Infobox drug/pregnancy category
Routes of; use	By mouth
Defined daily dose	2 grams
External links
AHFS/Drugs.com	Tɛmplet:Drugs.com
MedlinePlus	a696005
Legal
[[Regulation of therapeutic goods \|Tɛmplet:Engvar data]]	Tɛmplet:Infobox drug/licence
Legal status	Tɛmplet:Infobox drug/legal status
Pharmacokinetics
Bioavailability	50–60%
Protein binding	Minimal
Metabolism	Not by liver
Elimination half-life	4–8.7 hours
Excretion	Urine (90%)
Identifiers
CAS Number	Tɛmplet:Infobox drug/formatCASnumber; Tɛmplet:Infobox drug/formatCASnumber;
PubChem CID	Tɛmplet:Infobox drug/formatPubChemCID; Tɛmplet:Infobox drug/formatPubChemCID;
PubChem SID	Tɛmplet:Infobox drug/formatPubChemSID; Tɛmplet:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Tɛmplet:Infobox drug/formatIUPHARBPS; Tɛmplet:Infobox drug/formatIUPHARBPS;
DrugBank	Tɛmplet:Infobox drug/formatDrugBank; Tɛmplet:Infobox drug/formatDrugBank;
ChemSpider	Tɛmplet:Infobox drug/formatChemSpider; Tɛmplet:Infobox drug/formatChemSpider;
UNII	Tɛmplet:Infobox drug/formatUNII; Tɛmplet:Infobox drug/formatUNII;
KEGG	Tɛmplet:Infobox drug/formatKEGG; Tɛmplet:Infobox drug/formatKEGG;
ChEBI	Tɛmplet:Infobox drug/formatChEBI; Tɛmplet:Infobox drug/formatChEBI;
ChEMBL	Tɛmplet:Infobox drug/formatChEMBL; Tɛmplet:Infobox drug/formatChEMBL;
NIAID ChemDB	Tɛmplet:Infobox drug/formatChemDBNIAID; Tɛmplet:Infobox drug/formatChemDBNIAID;
PDB ligand	Tɛmplet:Infobox drug/formatPDBligand; Tɛmplet:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Tɛmplet:Infobox drug/formatCompTox; Tɛmplet:Infobox drug/formatCompTox;
ATC code	Tɛmplet:Infobox drug/formatATC; Tɛmplet:Infobox drug/formatATC;
Chemical and physical data
Formula	Tɛmplet:Infobox drug/chemical formula
Molar mass	Tɛmplet:Chem molar mass
3D model (JSmol)	Tɛmplet:Infobox drug/formatJmol; Tɛmplet:Infobox drug/formatJmol;
Density	1.3±0.1 g/cm3
	SMILES CN(C)C(=N)N=C(N)N;
	InChI InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8); Key:XZWYZXLIPXDOLR-UHFFFAOYSA-NTɛmplet:Stdinchicite;

Tɛmplet:Infobox drug/maintenance categories

Metformin, tila'shɛli niriba pam ni lahi mi Glucophage la ni yu' shɛŋa din gba ku pahi nyɛla tuuli ti' shɛli bɛ ni mali n tibiri shikiri doro.^[8]^[9], di bahi bahindi ninvuhi shɛba ban mali li ka nye ban malki ningbuna opam.^[10] Di lahi nyɛla tila' shɛli din tibiri polycystic ovary syndrome ^[8] Di ka nuu timbu niri ningbuna pahibu puuni. Di nyɛla ti'shɛli din vaani nɔli ni.^[8]

References

↑ (December 1978) "Disposition of metformin (N,N-dimethylbiguanide) in man". Clinical Pharmacology and Therapeutics 24 (6): 683–93. DOI:10.1002/cpt1978246683. PMID 710026.
1 2 Metformin Hydrochloride. The American Society of Health-System Pharmacists. Archived 24 Silimin gɔli December 2016 at the Wayback Machine
↑ METFORMIN oral - Essential drugs. Archived 29 Silimin gɔli August 2021 at the Wayback Machine
↑ WHOCC - ATC/DDD Index. Archived 17 Silimin gɔli September 2020 at the Wayback Machine
1 2 3 4 5 (May 1995) "Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus". Drugs 49 (5): 721–49. DOI:10.2165/00003495-199549050-00007. PMID 7601013.
↑ (2003) "Metformin: new understandings, new uses". Drugs 63 (18): 1879–94. DOI:10.2165/00003495-200363180-00001. PMID 12930161.
↑ metformin_msds. Archived 12 Silimin gɔli June 2017 at the Wayback Machine
1 2 3 Metformin Hydrochloride. The American Society of Health-System Pharmacists.
↑ (June 2016) "Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis". Annals of Internal Medicine 164 (11): 740–51. DOI:10.7326/M15-2650. PMID 27088241.
↑ Clinical Obesity (2nd ed.). Oxford: John Wiley & Sons. 2008. p. 262. ISBN 978-0-470-98708-7. Archived from the original on 2017-09-08.

[1] (December 1978) "Disposition of metformin (N,N-dimethylbiguanide) in man". Clinical Pharmacology and Therapeutics 24 (6): 683–93. DOI:10.1002/cpt1978246683. PMID 710026.

[AHFS2016-2] 1 2 Metformin Hydrochloride. The American Society of Health-System Pharmacists. Archived 24 Silimin gɔli December 2016 at the Wayback Machine

[MSF2020-3] METFORMIN oral - Essential drugs. Archived 29 Silimin gɔli August 2021 at the Wayback Machine

[WHO2020DDD-4] WHOCC - ATC/DDD Index. Archived 17 Silimin gɔli September 2020 at the Wayback Machine

[D95-5] 1 2 3 4 5 (May 1995) "Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus". Drugs 49 (5): 721–49. DOI:10.2165/00003495-199549050-00007. PMID 7601013.

[D03-6] (2003) "Metformin: new understandings, new uses". Drugs 63 (18): 1879–94. DOI:10.2165/00003495-200363180-00001. PMID 12930161.

[chemsrc-7] tformin_msds. Archived 12 Silimin gɔli June 2017 at the Wayback Machine

[AHFS20162-8] 1 2 3 Metformin Hydrochloride. The American Society of Health-System Pharmacists.

[Ann20162-9] (June 2016) "Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis". Annals of Internal Medicine 164 (11): 740–51. DOI:10.7326/M15-2650. PMID 27088241.

[10] Clinical Obesity (2nd ed.). Oxford: John Wiley & Sons. 2008. p. 262. ISBN 978-0-470-98708-7. Archived from the original on 2017-09-08.

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