Lorazepam

Tɛmplet:Infobox drug/title
Names
Trade names	Ativan, Tavor, Temesta, others
Other names	O-Chloroxazepam, L-Lorazepam Acetate
	IUPAC name 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one;
Clinical data
Drug class	Benzodiazepine
Main uses	Anxiety disorders, trouble sleeping, active seizures including status epilepticus, alcohol withdrawal, chemotherapy-induced nausea and vomiting
Side effects	Weakness, sleepiness, low blood pressure, decreased effort to breathe
WHO AWaRe	Script error: No such module "WDfetch".
Dependence risk	Low to moderate
Pregnancy; category	Tɛmplet:Infobox drug/pregnancy category
Routes of; use	By mouth, intramuscular, intravenous, under the tongue, and transdermal
Onset of action	1–5 min (IV), 15–30 min (IM)
Duration of action	12–24 hours
Urine detection	Up to 2 days
External links
AHFS/Drugs.com	Tɛmplet:Drugs.com
MedlinePlus	a682053
Legal
[[Regulation of therapeutic goods \|Tɛmplet:Engvar data]]	Tɛmplet:Infobox drug/licence
Legal status	Tɛmplet:Infobox drug/legal status
Pharmacokinetics
Bioavailability	85% when taken by mouth
Metabolism	Liver glucuronidation
Elimination half-life	10–20 hours
Excretion	Kidney
Identifiers
CAS Number	Tɛmplet:Infobox drug/formatCASnumber; Tɛmplet:Infobox drug/formatCASnumber;
PubChem CID	Tɛmplet:Infobox drug/formatPubChemCID; Tɛmplet:Infobox drug/formatPubChemCID;
PubChem SID	Tɛmplet:Infobox drug/formatPubChemSID; Tɛmplet:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Tɛmplet:Infobox drug/formatIUPHARBPS; Tɛmplet:Infobox drug/formatIUPHARBPS;
DrugBank	Tɛmplet:Infobox drug/formatDrugBank; Tɛmplet:Infobox drug/formatDrugBank;
ChemSpider	Tɛmplet:Infobox drug/formatChemSpider; Tɛmplet:Infobox drug/formatChemSpider;
UNII	Tɛmplet:Infobox drug/formatUNII; Tɛmplet:Infobox drug/formatUNII;
KEGG	Tɛmplet:Infobox drug/formatKEGG; Tɛmplet:Infobox drug/formatKEGG;
ChEBI	Tɛmplet:Infobox drug/formatChEBI; Tɛmplet:Infobox drug/formatChEBI;
ChEMBL	Tɛmplet:Infobox drug/formatChEMBL; Tɛmplet:Infobox drug/formatChEMBL;
NIAID ChemDB	Tɛmplet:Infobox drug/formatChemDBNIAID; Tɛmplet:Infobox drug/formatChemDBNIAID;
PDB ligand	Tɛmplet:Infobox drug/formatPDBligand; Tɛmplet:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Tɛmplet:Infobox drug/formatCompTox; Tɛmplet:Infobox drug/formatCompTox;
ATC code	Tɛmplet:Infobox drug/formatATC; Tɛmplet:Infobox drug/formatATC;
Chemical and physical data
Formula	Tɛmplet:Infobox drug/chemical formula
Molar mass	Tɛmplet:Chem molar mass
3D model (JSmol)	Tɛmplet:Infobox drug/formatJmol; Tɛmplet:Infobox drug/formatJmol;
	SMILES ClC1=CC=CC=C1C2=NC(C(NC3=C2C=C(C=C3)Cl)=O)O;
	InChI InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)Tɛmplet:Stdinchicite; Key:DIWRORZWFLOCLC-UHFFFAOYSA-NTɛmplet:Stdinchicite;

Tɛmplet:Infobox drug/maintenance categories

Lorazepam, bɛ ni lahi mi tila shɛli Ativan la nyɛla tila shɛli din pahi benzodiazepine zuliya puuni^[8] Di nyɛla tila shɛli din tibiri anxiety doriti, gom shee muɣisigu, kpilinkpihi, da' nyubo chebu, tiri kpuhibu din yirina Chemotherapy niŋbu shee hali ka tibiri tiri maŋ maŋa.^[8]

References

↑ Lorazepam.
1 2 3 4 Lorazepam. American Society of Health-System Pharmacists (June 29, 2016).
↑ Legal and Ethical Issues for Health Professions E-Book (in English). Elsevier Health Sciences. 2018. p. 90. ISBN 9780323550338. Archived from the original on 2021-03-11. Retrieved 2020-05-09.
↑ Interpreting Urine Drug Tests (UDT).
↑ (1991) "Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans". Journal of Pharmaceutical Sciences 68 (1): 57–63. DOI:10.1002/jps.2600680119. PMID 31453.
↑ (2000) "Kinetics and dynamics of lorazepam during and after continuous intravenous infusion". Critical Care Medicine 28 (8): 2750–2757. DOI:10.1097/00003246-200008000-00011. PMID 10966246.
↑ (2006) "Kinetic disposition of lorazepam with a focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples". Journal of Pharmaceutical and Biomedical Analysis 40 (2): 397–403. DOI:10.1016/j.jpba.2005.07.021. PMID 16143486.
1 2 Lorazepam. American Society of Health-System Pharmacists (June 29, 2016).

[1] Lorazepam.

[AHSP2016-2] 1 2 3 4 Lorazepam. American Society of Health-System Pharmacists (June 29, 2016).

[3] Legal and Ethical Issues for Health Professions E-Book (in English). Elsevier Health Sciences. 2018. p. 90. ISBN 9780323550338. Archived from the original on 2021-03-11. Retrieved 2020-05-09.

[4] Interpreting Urine Drug Tests (UDT).

[5] (1991) "Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans". Journal of Pharmaceutical Sciences 68 (1): 57–63. DOI:10.1002/jps.2600680119. PMID 31453.

[6] (2000) "Kinetics and dynamics of lorazepam during and after continuous intravenous infusion". Critical Care Medicine 28 (8): 2750–2757. DOI:10.1097/00003246-200008000-00011. PMID 10966246.

[kineticracemization-7] (2006) "Kinetic disposition of lorazepam with a focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples". Journal of Pharmaceutical and Biomedical Analysis 40 (2): 397–403. DOI:10.1016/j.jpba.2005.07.021. PMID 16143486.

[AHSP20162-8] 1 2 Lorazepam. American Society of Health-System Pharmacists (June 29, 2016).

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