Ibuprofen

Tɛmplet:Infobox drug/title
Names
Pronunciation	/ˈaɪbjuːproʊfɛn/, /aɪbjuːˈproʊfən/, EYE-bew-PROH-fən
Trade names	Advil, Motrin, Nurofen, others
Other names	isobutylphenylpropionic acid
	IUPAC name (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid;
Clinical data
Drug class	Nonsteroidal anti-inflammatory drug (NSAID)
Main uses	Pain, fever, inflammation
Side effects	Heartburn, rash
WHO AWaRe	Script error: No such module "WDfetch".
Pregnancy; category	Tɛmplet:Infobox drug/pregnancy category
Breastfeeding	Safe
Routes of; use	By mouth, rectal, topical, intravenous
Onset of action	30 min
Defined daily dose	1.2 g (by mouth) or; 1.2 g (parenteral) or; 1.2 g (rectal) for pain relief and; 30 mg (parenteral) for treatment of ischemic heart diseases
External links
AHFS/Drugs.com	Tɛmplet:Drugs.com
MedlinePlus	a682159
Legal
[[Regulation of therapeutic goods \|Tɛmplet:Engvar data]]	Tɛmplet:Infobox drug/licence
Legal status	Tɛmplet:Infobox drug/legal status
Pharmacokinetics
Bioavailability	80–100% (by mouth), 87% (rectal)
Protein binding	98%
Metabolism	Liver (CYP2C9)
Metabolites	ibuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen
Elimination half-life	2–4 h
Excretion	Urine (95%)
Identifiers
CAS Number	Tɛmplet:Infobox drug/formatCASnumber; Tɛmplet:Infobox drug/formatCASnumber;
PubChem CID	Tɛmplet:Infobox drug/formatPubChemCID; Tɛmplet:Infobox drug/formatPubChemCID;
PubChem SID	Tɛmplet:Infobox drug/formatPubChemSID; Tɛmplet:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Tɛmplet:Infobox drug/formatIUPHARBPS; Tɛmplet:Infobox drug/formatIUPHARBPS;
DrugBank	Tɛmplet:Infobox drug/formatDrugBank; Tɛmplet:Infobox drug/formatDrugBank;
ChemSpider	Tɛmplet:Infobox drug/formatChemSpider; Tɛmplet:Infobox drug/formatChemSpider;
UNII	Tɛmplet:Infobox drug/formatUNII; Tɛmplet:Infobox drug/formatUNII;
KEGG	Tɛmplet:Infobox drug/formatKEGG; Tɛmplet:Infobox drug/formatKEGG;
ChEBI	Tɛmplet:Infobox drug/formatChEBI; Tɛmplet:Infobox drug/formatChEBI;
ChEMBL	Tɛmplet:Infobox drug/formatChEMBL; Tɛmplet:Infobox drug/formatChEMBL;
NIAID ChemDB	Tɛmplet:Infobox drug/formatChemDBNIAID; Tɛmplet:Infobox drug/formatChemDBNIAID;
PDB ligand	Tɛmplet:Infobox drug/formatPDBligand; Tɛmplet:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Tɛmplet:Infobox drug/formatCompTox; Tɛmplet:Infobox drug/formatCompTox;
ATC code	Tɛmplet:Infobox drug/formatATC; Tɛmplet:Infobox drug/formatATC;
Chemical and physical data
Formula	Tɛmplet:Infobox drug/chemical formula
Molar mass	Tɛmplet:Chem molar mass
3D model (JSmol)	Tɛmplet:Infobox drug/formatJmol; Tɛmplet:Infobox drug/formatJmol;
Chirality	Racemic mixture
Density	1.03 g/ml g/cm3
Melting point	75 to 78 °C (167 to 172 °F)
Boiling point	157 °C (315 °F) at 4 mmHg
Solubility in water	0.021 mg/mL (20 °C)
	SMILES CC(C)Cc1ccc(cc1)[C@@H](C)C(=O)O;
	InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)Tɛmplet:Stdinchicite; Key:HEFNNWSXXWATRW-UHFFFAOYSA-NTɛmplet:Stdinchicite;

Tɛmplet:Infobox drug/maintenance categories

Ibuprofen nyɛla din pahi tila shɛŋa ban nye non-steroidal anti-inflammatory tilahi din tibiri biɛrim, ningbuŋ biili nti pahi inflammation^[10] Dɔri shɛŋa di ni tibiri maa shɛŋa n lahi n nye sɔrilim biɛrim, zuɣu yaali taliga, nti pahi rheumatoid arthritis^[10]

References

1 2 Ibuprofen. The American Society of Health-System Pharmacists.
↑ Ibuprofen use while Breastfeeding (en).
↑ ibuprofen.
↑ WHOCC - ATC/DDD Index. A chirim ya: Invalid parameter "name"who"" in <ref> tag. The supported parameters are: dir, follow, group, name.
↑ WHOCC - ATC/DDD Index.
↑ (November 2014) "Breastfeeding and migraine drugs". European Journal of Clinical Pharmacology 70 (11): 1313–24. DOI:10.1007/s00228-014-1748-0. PMID 25217187.
1 2 3 Davies, NM (February 1998). "Clinical pharmacokinetics of ibuprofen: The first 30 years.". Clinical Pharmacokinetics 34 (2): 101–54. DOI:10.2165/00003088-199834020-00002. PMID 9515184.
↑ (August 2017) "The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs". Trends in Pharmacological Sciences 38 (8): 733–48. DOI:10.1016/j.tips.2017.05.008. PMID 28651847.
↑ Brufen Tablets And Syrup (PDF). Therapeutic Goods Administration (31 July 2012).
1 2 Ibuprofen. The American Society of Health-System Pharmacists.

[AHFS2016-1] 1 2 Ibuprofen. The American Society of Health-System Pharmacists.

[Breast2021-2] Ibuprofen use while Breastfeeding (en).

[3] uprofen.

[4] WHOCC - ATC/DDD Index. A chirim ya: Invalid parameter "name"who"" in <ref> tag. The supported parameters are: dir, follow, group, name.

[who1-5] WHOCC - ATC/DDD Index.

[Davanzo2014-6] (November 2014) "Breastfeeding and migraine drugs". European Journal of Clinical Pharmacology 70 (11): 1313–24. DOI:10.1007/s00228-014-1748-0. PMID 25217187.

[clinp-7] 1 2 3 Davies, NM (February 1998). "Clinical pharmacokinetics of ibuprofen: The first 30 years.". Clinical Pharmacokinetics 34 (2): 101–54. DOI:10.2165/00003088-199834020-00002. PMID 9515184.

[Grosser2017-8] (August 2017) "The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs". Trends in Pharmacological Sciences 38 (8): 733–48. DOI:10.1016/j.tips.2017.05.008. PMID 28651847.

[TGA-9] Brufen Tablets And Syrup (PDF). Therapeutic Goods Administration (31 July 2012).

[AHFS20162-10] 1 2 Ibuprofen. The American Society of Health-System Pharmacists.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]