Fluoxetine

Tɛmplet:Infobox drug/title
	Fluoxetine (top),; (R)-fluoxetine (left), (S)-fluoxetine (right)
Names
Pronunciation	/fluˈɒksətiːn/
Trade names	Prozac, Sarafem, Adofen, other
	IUPAC name N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine;
Clinical data
Drug class	Selective serotonin reuptake inhibitor (SSRI)
WHO AWaRe	Script error: No such module "WDfetch".
Addiction risk	None
Pregnancy; category	Tɛmplet:Infobox drug/pregnancy category
Routes of; use	By mouth
Onset of action	2 to 3 weeks
Defined daily dose	20 milligram
External links
AHFS/Drugs.com	Tɛmplet:Drugs.com
MedlinePlus	a689006
Legal
[[Regulation of therapeutic goods \|Tɛmplet:Engvar data]]	Tɛmplet:Infobox drug/licence
Legal status	Tɛmplet:Infobox drug/legal status
Pharmacokinetics
Bioavailability	60–80%
Protein binding	94–95%
Metabolism	Liver (mostly CYP2D6-mediated)
Metabolites	norfluoxetine, desmethylfluoxetine
Elimination half-life	1–3 days (acute); 4–6 days (chronic)
Excretion	Urine (80%), faeces (15%)
Identifiers
CAS Number	Tɛmplet:Infobox drug/formatCASnumber; Tɛmplet:Infobox drug/formatCASnumber;
PubChem CID	Tɛmplet:Infobox drug/formatPubChemCID; Tɛmplet:Infobox drug/formatPubChemCID;
PubChem SID	Tɛmplet:Infobox drug/formatPubChemSID; Tɛmplet:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Tɛmplet:Infobox drug/formatIUPHARBPS; Tɛmplet:Infobox drug/formatIUPHARBPS;
DrugBank	Tɛmplet:Infobox drug/formatDrugBank; Tɛmplet:Infobox drug/formatDrugBank;
ChemSpider	Tɛmplet:Infobox drug/formatChemSpider; Tɛmplet:Infobox drug/formatChemSpider;
UNII	Tɛmplet:Infobox drug/formatUNII; Tɛmplet:Infobox drug/formatUNII;
KEGG	Tɛmplet:Infobox drug/formatKEGG; Tɛmplet:Infobox drug/formatKEGG;
ChEBI	Tɛmplet:Infobox drug/formatChEBI; Tɛmplet:Infobox drug/formatChEBI;
ChEMBL	Tɛmplet:Infobox drug/formatChEMBL; Tɛmplet:Infobox drug/formatChEMBL;
NIAID ChemDB	Tɛmplet:Infobox drug/formatChemDBNIAID; Tɛmplet:Infobox drug/formatChemDBNIAID;
PDB ligand	Tɛmplet:Infobox drug/formatPDBligand; Tɛmplet:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Tɛmplet:Infobox drug/formatCompTox; Tɛmplet:Infobox drug/formatCompTox;
ATC code	Tɛmplet:Infobox drug/formatATC; Tɛmplet:Infobox drug/formatATC;
Chemical and physical data
Formula	Tɛmplet:Infobox drug/chemical formula
Molar mass	Tɛmplet:Chem molar mass
3D model (JSmol)	Tɛmplet:Infobox drug/formatJmol; Tɛmplet:Infobox drug/formatJmol;
Chirality	Racemic mixture
Melting point	179 to 182 °C (354 to 360 °F)
Boiling point	395 °C (743 °F)
Solubility in water	14 mg/mL (20 °C)
	SMILES CNCCC(c1ccccc1)Oc2ccc(cc2)C(F)(F)F;
	InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3Tɛmplet:Stdinchicite; Key:RTHCYVBBDHJXIQ-UHFFFAOYSA-NTɛmplet:Stdinchicite;

Tɛmplet:Infobox drug/maintenance categories

Fluoxetine, bɛ lahi mi shɛli Prozac bee Sarafem la nyɛla tila shɛli din nye anitidepressant nka lahi nye din pahi selective serotonin reuptake inhibitor (SSRI) zuliya puuni^[8]

References

1 2 Fluoxetine Hydrochloride. The American Society of Health-System Pharmacists.
↑ Hubbard, John R.; Martin, Peter R. (2001). Substance Abuse in the Mentally and Physically Disabled (in English). CRC Press. p. 26. ISBN 9780824744977. Archived from the original on 1 August 2020. Retrieved 3 August 2020.
↑ FLUOXETINE oral - Essential drugs.
↑ WHOCC – ATC/DDD Index.
↑ Prozac Label. FDA (2014).
1 2 3 PROZAC® Fluoxetine Hydrochloride (PDF). TGA eBusiness Services. Eli Lilly Australia Pty. Limited (9 October 2013).
1 2 (March 1994) "Clinical pharmacokinetics of fluoxetine". Clinical Pharmacokinetics 26 (3): 201–14. DOI:10.2165/00003088-199426030-00004. PMID 8194283.
↑ Propofol. The American Society of Health-System Pharmacists.

[AHFS2015-1] 1 2 Fluoxetine Hydrochloride. The American Society of Health-System Pharmacists.

[Hub2001-2] Hubbard, John R.; Martin, Peter R. (2001). Substance Abuse in the Mentally and Physically Disabled (in English). CRC Press. p. 26. ISBN 9780824744977. Archived from the original on 1 August 2020. Retrieved 3 August 2020.

[MSF2020-3] FLUOXETINE oral - Essential drugs.

[WHOCC-4] WHOCC – ATC/DDD Index.

[ProzacLabel2014-5] Prozac Label. FDA (2014).

[TGA-6] 1 2 3 PROZAC® Fluoxetine Hydrochloride (PDF). TGA eBusiness Services. Eli Lilly Australia Pty. Limited (9 October 2013).

[PK-7] 1 2 (March 1994) "Clinical pharmacokinetics of fluoxetine". Clinical Pharmacokinetics 26 (3): 201–14. DOI:10.2165/00003088-199426030-00004. PMID 8194283.

[AHFS20162-8] Propofol. The American Society of Health-System Pharmacists.

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