Fentanyl
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| Names | |
|---|---|
| Pronunciation | /ˈfɛntənɪl/ or /ˈfɛntənəl/ |
| Trade names | Actiq, Duragesic, Fentora, others |
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| Clinical data | |
| Drug class | Opioid |
| WHO AWaRe | Script error: No such module "WDfetch". |
| Dependence risk | High[1] |
| Pregnancy category | Tɛmplet:Infobox drug/pregnancy category |
| Routes of use | Buccal, epidural, IM, IT, IV, sublingual, skin patch |
| Onset of action | 5 minutes[2] |
| Duration of action | IV: 30–60 minutes[2][3] |
| Defined daily dose | 600 ug (nasal, under tongue)[4] 1,200 ug (skin patch)[4] |
| Urine detection | 2 days to 4 wks[5] |
| External links | |
| AHFS/Drugs.com | Tɛmplet:Drugs.com |
| MedlinePlus | a605043 |
| Legal | |
| [[Regulation of therapeutic goods |Tɛmplet:Engvar data]] | Tɛmplet:Infobox drug/licence |
| Legal status | Tɛmplet:Infobox drug/legal status |
| Pharmacokinetics | |
| Bioavailability | 92% (transdermal) 89% (intranasal) 50% (buccal) 33% (ingestion) 100% (intramuscular)/> 55% (inhaled) |
| Protein binding | 80–85% |
| Metabolism | Liver, primarily by CYP3A4 |
| Elimination half-life | IV: 6 mins (T1/2 α) 1 hours (T1/2 β) 16 hours (T1/2 ɣ) Intranasal: 6.5 hours Transdermal: 20–27 hours[6] Sublingual/buccal (single dose): 2.6–13.5 hours[6] |
| Excretion | Mostly urinary (metabolites, <10% unchanged drug)[6] |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| PubChem SID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| NIAID ChemDB | |
| PDB ligand | |
| CompTox Dashboard (EPA) | |
| ATC code | |
| Chemical and physical data | |
| Formula | Tɛmplet:Infobox drug/chemical formula |
| Molar mass | Tɛmplet:Chem molar mass |
| 3D model (JSmol) | |
| Density | 1.1 g/cm3 |
| Melting point | 87.5 °C (189.5 °F) |
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Tɛmplet:Infobox drug/maintenance categories
Fentanyl, bee bɛ ni lahi sabiri shɛli fentanil, pahila tila' shɛŋa bɛ ni bɔli opoid la ka di nyɛla tila' shɛli din kuri ningbuŋ biɛrim ka bɛ mali li n pahiri tila shɛŋa din gba pahi bi yi ti yɛn niŋ anesthesia.[7] Fentanyl gba tooi nye nachinsi tilaa, ka niriba tooi mali li gabiri a Heroin bee Cocaine puuni.[8] Ti tumbu ningbuŋ puuni bɛ yuuri a ka di yaa gba lahi yiri yom yom ka mani awa diba ayi sunsuuni[7] Ashibiti tuma yaɣili ni, bɛ chibiri a Fentanyl n niŋdi sali ningbuŋ ni, bee ka bɛ ŋmaɣim li n niŋ o nyee ni, bee ka bɛ zaŋ li n pa o ningbuŋ zuɣu, bee ka bɛ zaŋ li n niŋ o nyin'bayaɣatini, ka nyɛla lozenge bee ti' kpula [7][9]
References
[mali niŋ | mali mi di yibu sheena n-niŋ]- ↑ Bonewit-West, Kathy; Hunt, Sue A.; Applegate, Edith (2012). Today's Medical Assistant: Clinical and Administrative Procedures (in English). Elsevier Health Sciences. p. 571. ISBN 9781455701506. Archived from the original on 2020-07-28. Retrieved 2020-08-06.
- 1 2 Clinically Oriented Pharmacology (2 ed.). Quick Review of Pharmacology. 2010. p. 172.
- ↑ Guideline for administration of fentanyl for pain relief in labour. RCP. “Onset of action after IV administration of Fentanyl is 3–5 minutes; duration of action is 30–60 minutes.”
- 1 2 WHOCC - ATC/DDD Index.
- ↑ Interpreting Urine Drug Tests (UDT).
- 1 2 3 Fentanyl, Fentanyl Citrate, Fentanyl Hydrochloride. The American Society of Health-System Pharmacists.
- 1 2 3 Fentanyl, Fentanyl Citrate, Fentanyl Hydrochloride. The American Society of Health-System Pharmacists.
- ↑ Fentanyl Drug Overdose (29 August 2017).
- ↑ tablets.