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vemurafenib

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chemical compound

External resources

Binsheli di niŋdi bini
/m/0hqvq1s[1]
Reaxys registry number
12833468[2]
PubChem CID
42611257[3][4]
MeSH descriptor ID
D000077484

Din yuli nyɛ: Vemurafenib

UniChem compound ID
649459[5]
Quora topic ID
Vemurafenib[6]
LiverTosi dalinli
Vemurafenib
PDB ligand ID
032
KEGG ID
D09996[2]
UNII
207SMY3FQT[7][4]
ATC code
L01XE15[8]
DeCS dalinli
57657
PDB structure ID
3OG7[9]
5HES[10]
4RZV[11]
OpenAlex ID
C2776131300[12]
ChEMBL ID
CHEMBL1229517[13]
DrugBank ID
DB08881[4]
BBC binyɛra ID
513b52df-f7fb-4032-9537-4d0e25ce26f0[14]
InChIKey
GPXBXXGIAQBQNI-UHFFFAOYSA-N[3][15]
SPLASH
splash10-0006-0024900000-4911e6c7ad52fd2c2896
Human Metabolome Database ID
HMDB0259779[16][4]
CAS rigistibu kalinli
918504-65-1[2][17]
ChEBI ID
63637[2][18]

mapping ŋmahin gbana: exact match

WikiProjectMed ID
Vemurafenib
InChI
InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)[3]
National Drug Code
50242-090
SureChEMBL ID
SCHEMBL298931[4]
MeSH tia code
D02.065.884.919
D02.886.590.700.919
D03.633.100.473.936
Microsoft Academic ID
2776131300
Guide to Pharmacology Ligand ID
5893[19]
HSDB ID
8143[20]
UMLS CUI
C3192263
DSSTOX compound identifier
DTXCID00161201
PatientsLikeMe treatment ID
vemurafenib
ECHA Substance Infocard ID
100.287.801
MedlinePlus drug identifier
a612009
ChemSpider ID
24747352[21]
EC lamba
850-250-7
NDF-RT dalinli
N0000183250[22]
DrugCentral ID
4185[5]
World Health Organisation international non-proprietary name numeric ID
9286
DSSTox substance ID
DTXSID50238710[23][4]
RxNorm ID
1147220
Probes And Drugs ID
PD003414

buɣusi la

type of chemical entity

yaɣ sheli

chemical compound

Di bukaata

tima

tima yaɣa

timsim

489.073 dalton[3]

chemical formula

C₂₃H₁₈ClF₂N₃O₃S[3]

canonical SMILES

CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F[3]

active ingredient in

Zelboraf[24]

World Health Organisation international non-proprietary name

vemurafenib[2]

medical condition treated

hairy cell leukemia[25]
metastatic melanoma[25]
skin cancer[25]
Erdheim-Chester disease[25]
melanoma[25]

significant drug interaction

efavirenz[26]

barina: long QT syndrome

theophylline monohydrate[26]

barina: Achor-Smith syndrom

fosphenytoin[26]

barina: long QT syndrome

taba laɣim di fiila

B-Raf proto-oncogene, serine/threonine kinase[27]

bachikpani mali tuma: enzyme inhibitor

Raf-1 proto-oncogene, serine/threonine kinase[27]

bachikpani mali tuma: enzyme inhibitor

pregnancy category

Australian pregnancy category D
US pregnancy category D

LiverTox likelihood score

LiverTox toxicity likelihood category E*[28]

bachikpani mali tuma

antineoplastic[29]
protein kinase inhibitors[30]
xenobiotic-transporting ATPase inhibitor[30]
enzyme inhibitor[29]

pubu Commons ni

Vemurafenib

Reference

  1. ↑ Freebase Data Dumps, 28 Silimin gɔli October 2013
  2. ↑ 2.0 2.1 2.2 2.3 2.4 ChEBI, 18 Silimin gɔli October 2016, Silmiinsili, vemurafenib, 63637
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 PubChem, 18 Silimin gɔli October 2016, Silmiinsili, 42611257, Vemurafenib
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 GPXBXXGIAQBQNI-UHFFFAOYSA-N, InChIKey
  5. ↑ 5.0 5.1 UniChem
  6. ↑ Quora
  7. ↑ Global Substance Registration System, 18 Silimin gɔli October 2016, Silmiinsili, vemurafenib, 207SMY3FQT
  8. ↑ DrugBank, Silmiinsili, 17 Silimin gɔli November 2015, 08881, Vemurafenib
  9. ↑ Protein Data Bank, 18 Silimin gɔli October 2016, Silmiinsili, 3OG7, 3OG7
  10. ↑ Protein Data Bank, 18 Silimin gɔli October 2016, Silmiinsili, 5HES, 5HES
  11. ↑ Protein Data Bank, 18 Silimin gɔli October 2016, Silmiinsili, 4RZV, 4RZV
  12. ↑ OpenAlex, 26 Silimin gɔli January 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  13. ↑ ChEMBL, 18 Silimin gɔli October 2016, Silmiinsili, VEMURAFENIB, CHEMBL1229517
  14. ↑ BBC Things
  15. ↑ ChEBI release 2020-09-01
  16. ↑ inferred from InChIKey
  17. ↑ CAS Common Chemistry, 8 Silimin gɔli April 2021, https://commonchemistry.cas.org/detail?cas_rn=918504-65-1, GPXBXXGIAQBQNI-UHFFFAOYSA-N
  18. ↑ InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28), International Chemical Identifier
  19. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 18 Silimin gɔli October 2016, Silmiinsili, 5893, vemurafenib
  20. ↑ Hazardous Substances Data Bank, 10 Silimin gɔli May 2021, 28 Silimin gɔli October 2019, Vemurafenib, 8143
  21. ↑ ChemSpider, 18 Silimin gɔli October 2016, Silmiinsili, 24747352, Vemurafenib
  22. ↑ NDF-RT, 19 Silimin gɔli January 2016, Silmiinsili, VEMURAFENIB, N0000183250
  23. ↑ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
  24. ↑ RxNorm, 1147224, 14 Silimin gɔli February 2018
  25. ↑ 25.0 25.1 25.2 25.3 25.4 Drug Indications Extracted from FAERS, 2 Silimin gɔli October 2018
  26. ↑ 26.0 26.1 26.2 A reference set of clinically relevant adverse drug-drug interactions, hypothetically
  27. ↑ 27.0 27.1 IUPHAR/BPS Guide to PHARMACOLOGY, 17 Silimin gɔli August 2016, 5893, Silmiinsili
  28. ↑ LiverTox, 8 Silimin gɔli April 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Vemurafenib, 28 Silimin gɔli June 2018
  29. ↑ 29.0 29.1 Medical Subject Headings, 15 Silimin gɔli March 2018, C551177
  30. ↑ 30.0 30.1 N0000183250, 5 Silimin gɔli March 2018, NDF-RT
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