Amitriptyline

Tɛmplet:Infobox drug/title
Names
Pronunciation	/ˌæmɪˈtrɪptɪliːn/
Trade names	Elavil, others
Other names	Amitryptyline; Amytriptyline; Amitryptiline; Amitriptiline; MK-230; N-750; Ro 4-1575
	IUPAC name 3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine;
Clinical data
Drug class	Tricyclic antidepressant (TCA)
Main uses	Major depression, neuropathic pain
Side effects	Sleepiness, low blood pressure on standing, dry mouth, mental confusion
WHO AWaRe	Script error: No such module "WDfetch".
Pregnancy; category	Tɛmplet:Infobox drug/pregnancy category
Routes of; use	By mouth, intramuscular injection
Defined daily dose	75 mg
External links
AHFS/Drugs.com	Tɛmplet:Drugs.com
MedlinePlus	a682388
Legal
[[Regulation of therapeutic goods \|Tɛmplet:Engvar data]]	Tɛmplet:Infobox drug/licence
Legal status	Tɛmplet:Infobox drug/legal status
Pharmacokinetics
Bioavailability	30–60%
Protein binding	96%
Metabolism	Liver (CYP2D6, CYP2C19)
Metabolites	nortriptyline
Elimination half-life	10–50 hours
Excretion	Urine
Identifiers
CAS Number	Tɛmplet:Infobox drug/formatCASnumber; Tɛmplet:Infobox drug/formatCASnumber;
PubChem CID	Tɛmplet:Infobox drug/formatPubChemCID; Tɛmplet:Infobox drug/formatPubChemCID;
PubChem SID	Tɛmplet:Infobox drug/formatPubChemSID; Tɛmplet:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Tɛmplet:Infobox drug/formatIUPHARBPS; Tɛmplet:Infobox drug/formatIUPHARBPS;
DrugBank	Tɛmplet:Infobox drug/formatDrugBank; Tɛmplet:Infobox drug/formatDrugBank;
ChemSpider	Tɛmplet:Infobox drug/formatChemSpider; Tɛmplet:Infobox drug/formatChemSpider;
UNII	Tɛmplet:Infobox drug/formatUNII; Tɛmplet:Infobox drug/formatUNII;
KEGG	Tɛmplet:Infobox drug/formatKEGG; Tɛmplet:Infobox drug/formatKEGG;
ChEBI	Tɛmplet:Infobox drug/formatChEBI; Tɛmplet:Infobox drug/formatChEBI;
ChEMBL	Tɛmplet:Infobox drug/formatChEMBL; Tɛmplet:Infobox drug/formatChEMBL;
NIAID ChemDB	Tɛmplet:Infobox drug/formatChemDBNIAID; Tɛmplet:Infobox drug/formatChemDBNIAID;
PDB ligand	Tɛmplet:Infobox drug/formatPDBligand; Tɛmplet:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Tɛmplet:Infobox drug/formatCompTox; Tɛmplet:Infobox drug/formatCompTox;
ATC code	Tɛmplet:Infobox drug/formatATC; Tɛmplet:Infobox drug/formatATC;
Chemical and physical data
Formula	Tɛmplet:Infobox drug/chemical formula
Molar mass	Tɛmplet:Chem molar mass
3D model (JSmol)	Tɛmplet:Infobox drug/formatJmol; Tɛmplet:Infobox drug/formatJmol;
Melting point	188 °C (370 °F)
	SMILES c3cc2c(/C(c1c(cccc1)CC2)=C\CCN(C)C)cc3;
	InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3Tɛmplet:Stdinchicite; Key:KRMDCWKBEZIMAB-UHFFFAOYSA-NTɛmplet:Stdinchicite;

Tɛmplet:Infobox drug/maintenance categories

Amitriptyline, bɛ ni lahi mi tila shɛli Elavil la nyɛla tila shɛli di tuuli tuma n-nye yinyahili ni din kam ŋmanli ^[5]

References

↑ Oxford Dictionary: Definition of amitriptyline (British & World English) Archived 14 Silimin gɔli July 2014 at the Wayback Machine
1 2 AMITRIPTYLINE oral - Essential drugs. Archived 27 Silimin gɔli August 2021 at the Wayback Machine
↑ WHOCC - ATC/DDD Index. Archived 21 Silimin gɔli October 2020 at the Wayback Machine
1 2 3 4 Amitriptyline Hydrochloride. The American Society of Health-System Pharmacists. Archived 24 Silimin gɔli September 2014 at the Wayback Machine
↑ Amitriptyline Hydrochloride. The American Society of Health-System Pharmacists. Archived 24 Silimin gɔli September 2014 at the Wayback Machine

[1] Oxford Dictionary: Definition of amitriptyline (British & World English) Archived 14 Silimin gɔli July 2014 at the Wayback Machine

[MSF2020-2] 1 2 AMITRIPTYLINE oral - Essential drugs. Archived 27 Silimin gɔli August 2021 at the Wayback Machine

[who-3] WHOCC - ATC/DDD Index. Archived 21 Silimin gɔli October 2020 at the Wayback Machine

[AHFS2014-4] 1 2 3 4 Amitriptyline Hydrochloride. The American Society of Health-System Pharmacists. Archived 24 Silimin gɔli September 2014 at the Wayback Machine

[AHFS20142-5] Amitriptyline Hydrochloride. The American Society of Health-System Pharmacists. Archived 24 Silimin gɔli September 2014 at the Wayback Machine

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